In 2021, melatonin was the most frequently reported substance involved in pediatric substance ingestions, resulting in 4,000 hospitalizations, 287 ICU admissions, and 2 deaths in children under the age of 2. Melatonin supplements can have 500% more melatonin than indicated on the label and about 30% of OTC products tested had serotonin as well.

The first in a two-part series, this 0.50-credit, 30-minute CME multiplatform program discusses the importance of early identification of AD and how to detect it early, the pathobiology of AD and potential treatments in development to target this pathology, and current treatment options, including the appropriate use of anti-amyloid monoclonal antibody (mAb) treatment.

Using covariate analysis of records from more than 1.2 million children over 17 years, these researchers conclude that the elevated risk for neonatal seizures and childhood epilepsy in children who were exposed to SSRIs or SNRIs during pregnancy can be attributed to the indicated SSRI and SNRI use for pregnant women, history of parental epilepsy, and other covariates, rather than the use of the medication itself.

From a cohort of approximately 21,000 people in the UK, alcohol consumption above about 4 drinks per week was associated with markers of higher brain iron in multiple basal ganglia regions, which was in turn associated with poorer scores on tests of executive function, fluid intelligence, and reaction speed.

Selecting effective antidepressants for the treatment of major depressive disorder is an imprecise practice. With remission rates of about 30% after the initial therapy selection, there is a need to uncover biomarkers able to predict treatment response. This study looked at pharmacogenomic testing for drug-gene interactions to guide treatment selection. Unfortunately, they did not find significantly improved outcomes.

A conversation with Ann Marie Navar, MD, PhD, associate professor of cardiology at UT Southwestern in Dallas, Texas and associate editor of JAMA Cardiology, who discusses common statin-related myths, the safety of statin therapy, and reliable sources of information for patients.