Some countries have adopted the DSM-5 classification for PTSD, which currently doesn’t list a diagnosis for complex PTSD. The WHO is hoping to change that, as the group recently listed a sibling diagnosis for PTSD, the complex post-traumatic stress disorder (CPTSD), which occurs after prolonged or repetitive exposure to traumatic events.

There are no approved medications for the core symptoms of autism spectrum disorder (ASD), socialization and communication difficulties. Did balovaptan, an oral selective vasopressin 1a receptor antagonist, help us get closer to an approved drug?

With treatment penetration rates less than 20% for those with serious addictions, this viewpoint offers up a strategic clinical approach that mimics the diabetes field, using the term preaddiction, a commonly understood, motivating term (such as prediabetes) that could engender broader clinical efforts to effect the planned strategy.

In 2019, the FDA warned that gabapentin might cause serious breathing difficulties when used with drugs that depress the central nervous system. The warning may have not been heeded, as overdose deaths in which gabapentin was detected doubled from 449 in the first quarter of 2019 to 959 in the second quarter of 2020.

In this Journal Club discussion, among participants in the vaccine-CD20-vaccine cohort, 100% of participants experienced a measurable response to a third dose of a COVID-19 vaccine compared with 18% in the CD20-vaccine cohort.

As this review discovered, repurposing of established noradrenergic drugs is most likely to offer effective treatment in Alzheimer’s disease for general cognition and apathy. Still, the report offers several factors that should be considered before designing future clinical trials.