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GoodRx HealthCan You Drink Coffee With Blood Pressure Meds? 10 Medications That Interact With Caffeine

Caffeine and Medication Interactions: Implications for Patient Management

Caffeine, a ubiquitous stimulant found in coffee, tea, and many energy drinks, plays a significant role in daily routines worldwide. Although its stimulating effects are widely appreciated, caffeine can also interact with various medications, potentially impacting their efficacy and safety. This article provides a comprehensive overview of these interactions, offering crucial insights for healthcare professionals managing patients on these medications.

Key Points:

  1. Blood Pressure Medications: Although caffeine does not directly interact with blood pressure medications, it can elevate blood pressure levels, potentially complicating the management of hypertension. Limiting caffeine is advisable, with one or two cups generally being acceptable.
  2. Stimulant Medications: Caffeine can exacerbate the side effects of stimulant drugs such as Adderall and phentermine, leading to increased heart rate, blood pressure, and other severe symptoms. Patients on these medications should consider reducing their caffeine intake.
  3. Sudafed (pseudoephedrine): The combination of caffeine and Sudafed can heighten the risk of cardiovascular side effects and disrupt sleep, making it advisable to avoid caffeine while taking this medication.
  4. Theophylline: Used in asthma and COPD, theophylline’s side effects can be intensified by caffeine, necessitating a limit on caffeine consumption for affected patients.
  5. Antipsychotics: Caffeine can increase blood levels of certain antipsychotics, such as olanzapine, potentially enhancing side effects and affecting medication efficacy.
  6. Anxiety and Sleep Medications: As a stimulant, caffeine can counteract the effects of sedatives, worsening conditions like insomnia and anxiety. It is recommended to avoid caffeine several hours before bedtime.
  7. Oral Contraceptive Pills: These can slow caffeine metabolism, prolonging its effects and potentially disrupting sleep, suggesting a reduction in caffeine intake might be beneficial.
  8. Diabetes Medications: Caffeine can decrease insulin sensitivity and raise post-meal blood glucose levels, complicating diabetes management.
  9. Thyroid Hormone Medications: Coffee can reduce the absorption of thyroid hormone medications; a delay of at least 60 minutes between coffee and medication is recommended.
  10. Tricyclic Antidepressants: Caffeine can raise the levels of these medications, increasing the risk of side effects such as dizziness and constipation.

Grapefruit juice consumption decreases caffeine clearance by 23% and prolongs half-life by 31%. (Coffee & Health)

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