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A phase 3 trial demonstrates that aficamten improves oxygen utilization during exercise for obstructive HCM patients, indicating its potential to enhance daily functionality and quality of life.
Cardiology June 18th 2024
The New England Journal of Medicine
In a phase 2b trial, plozasiran significantly reduced fasting triglyceride levels at 24 weeks in patients with mixed hyperlipidemia, with the 50 mg quarterly dose achieving a mean reduction of 62.4 percentage points. This study highlights the potential of APOC3 inhibition as a therapeutic strategy for lipid management.
Cardiology June 7th 2024
A 70-year-old diabetic woman presented with epigastric pain and was diagnosed with a transmural anteroseptal myocardial infarction complicated by a left ventricular thrombus. Using an image, this case reinforces the critical importance of recognizing and managing late-presenting myocardial infarction.
Cleveland Clinic Journal of Medicine
In lung transplant recipients presenting with acute respiratory symptoms, a broad differential diagnosis and prompt, comprehensive evaluation are crucial. This case highlights the significance of considering opportunistic infections and the necessity of early empiric antimicrobial therapy to prevent rapid deterioration.
Hypoglossal nerve stimulation, a newer surgical option for obstructive sleep apnea, shows high adherence and durable benefits, significantly reducing AHI and improving patient outcomes.
Measuring exhaled nitric oxide (FeNO) aids in diagnosing asthma, predicting response to corticosteroids, and monitoring treatment adherence, making it a valuable adjunctive tool in comprehensive asthma management.