Articles related to Endocrinology, Diabetes, Metabolism

Data on more than 200,000 individuals revealed that non-SSRI antidepressants were associated with a two-fold increased risk of coronary heart disease, cardiovascular mortality, and all-cause mortality at ten years. There was also evidence that SSRIs were associated with lower rates of hypertension and diabetes.

Nearly 20,000 mother-child pairs were tracked over a median follow-up of 4 years. After adjusting for maternal risk factors and their children’s own ultra-processed food intake, physical activity, and sedentary time, maternal consumption of ultra-processed foods during the child-rearing period was associated with overweight or obesity in offspring with a 26% higher risk in the group with the highest maternal ultra-processed food consumption.

In the 5-year, multi-center, randomized, controlled GRADE trial (Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study), insulin glargine and liraglutide were about 13% more effective than glimepiride in keeping HbA1c lower than 7.0%, and 30% more effective than sitagliptin.

Because this GLP-1 agonist is known to reduce food intake, physicians have been prescribing tirzepatide off-label for weight loss for years. But unlike other drugs in its class, tirzepatide targets GLP-1 and GIP receptors.

Questions run across a host of topics, and in September you can challenge yourself in mortality risk, myocardial infarction (MI), insomnia, liver cancer, lipids, and Parkinson’s disease guidelines. Each question is worth 4 points with bonuses for quick response. Speed matters in this quiz. Why not give it a try and see if you can get on the leaderboard of the Smartest Doc?

The founding editor of Comprehensive Clinical Nephrology teases out for us our physiologic response to salt, sugar, fat, and water that creates a recipe for obesity – a recipe being used daily by many Americans with obvious results. His recommendation? “Drinking more water and reducing salt intake offer cheap, easy and healthy strategies that may prevent or treat obesity.” Click to see the evidence behind the conclusion.