Articles related to Oncology, Surgical

Antihistamine use in patients with HBV, HCV, or dual virus infections was associated with approximately two-fold lower risk of HCC when compared with patients who did not use antihistamines, in a dose-dependent manner.

Neo-adjuvant therapy with nivolumab and ipilimumab is associated with a high pCR rate in ptsd with MSI/dMMR resectable OGA.

When tested in mice with pancreatic cancer, a BET inhibitor/anti-PD-1 combination prevented neoplastic transformation induced by the oncogene KRAS, increased survival and increased the recruitment of cytotoxic T-cells to the tumor.

The phase 3 RATIONALE 306 trial of tislelizumab plus chemotherapy significantly improved OS compared to chemotherapy alone in patients with previously untreated advanced esophageal squamous cell carcinoma.

In this updated analysis of the KEYNOTE-177 study, although pembrolizumab continued to show durable antitumor activity and fewer treatment-related adverse events compared with chemotherapy, there was no significant difference in overall survival between the two treatment groups.

Results of a MEDLINE review highlight numerous studies across different cancer types indicating that ctDNA-based MRD detection predicts recurrence with high sensitivity and specificity, and with lead times that precede standard imaging by up to 12 months.