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OBR OncologyLung Cancer Takes Center Stage at ESMO Congress 2023 with New Drugs, More Options

Alectinib shows promise as an ALK inhibitor to improve disease-free survival, while the amivantamab-lazerinib combo demonstrated improved PFS

The European Society for Medical Oncology (ESMO) Congress 2023 in Madrid, Spain, taking place from October 20 – 24, 2023, has been a hotbed of advancements in non-small cell lung cancer (NSCLC) treatments. With seven of the 15 late-breaking abstracts focusing on NSCLC, the congress has showcased a range of promising new drugs and treatment strategies.

HCN Medical Memo
It’s important to note the significant advancements presented at the ESMO Congress 2023. The ALINA and MARIPOSA trials have shown promising results for NSCLC treatments. Alectinib, in particular, has emerged as a potential game-changer for patients with completely resected ALK-positive NSCLC. These developments could potentially shift our approach towards NSCLC treatment, emphasizing the importance of early detection and biomarker testing.

Key Points

  • The global phase 3 ALINA trial tested the efficacy and safety of the ALK inhibitor alectinib (Alecensa) as an adjuvant therapy compared with platinum-based chemotherapy in patients with completely resected ALK-positive NSCLC.
    • The released results show that alectinib is the first ALK inhibitor to significantly improve disease-free survival compared with chemotherapy.
  • The phase 3 MARIPOSA trial compared amivantamab (Rybrevant) in combination with lazertinib (Leclaza) versus osimertinib (Tagrisso) as first-line treatment in patients with EGFR-mutated advanced NSCLC.
    • The results show that the combination of amivantamab and lazertinib significantly improved progression-free survival with longer duration of response, favorable overall survival trend, and a safety profile that is consistent with prior reports.

HCN Conference Concierge

  • Retiro Park: A sprawling swath of lush greenery filled with formal gardens, lakes, cafes, playgrounds and more.
  • Museo Nacional Thyssen-Bornemisza: A must-visit for art lovers, this museum houses an extensive collection of artworks.
  • Los Montes de Galicia: Known for its exceptional service and delicious food.
  • La Esquina del Real: Another great restaurant in Madrid offering a variety of dishes

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