Articles related to BIRTH DEFECTS

This study reveals a paradigm shift in managing patent ductus arteriosus in preterm infants, highlighting expectant management’s noninferiority to early ibuprofen treatment in reducing critical neonatal morbidities.

ART-conceived singleton infants had an elevated risk for major genitourinary abnormalities. This risk remained unchanged even when accounting for parental infertility.

This study offers valuable insights into the optimal timing for cleft palate surgery in infants, showing a lower risk of velopharyngeal insufficiency when surgery is performed at 6 months. Consider this data when planning surgical interventions and advising parents.

Although research exists on the impact of CNS stimulants used in pregnancy, only a few small studies have looked at atomoxetine and pregnancy outcomes. This large cohort study of 4.2 million pregnancies ending in live births in northern Europe and the US reviewed nearly 1,000 pregnancies exposed to atomoxetine in the first trimester. Compared with non-exposed pregnancies, there was no observed increase in major congenital abnormalities with atomoxetine use in the first trimester.

Diabetes medications, such as metformin, have glucose-independent effects on the male reproductive system. However, until now, it was unknown if these effects lead to birth defects in offspring. This study concludes that metformin intake in men is associated with major birth defects, particularly genital birth defects in boys.