Articles related to CLINICAL STUDY

According to structural modeling, preschoolers’ and their families’ oral health-related quality of life (OHRQoL) was severely impacted by the severity of early childhood caries (ECC). Weaker socioeconomic position, greater frequency of free sugar consumption, and weaker parental resilience were the key risk factors for the severity of ECC. The results show that psychosocial and behavioral factors might influence how severe ECC is, and that ECC can have a detrimental impact on preschoolers’ welfare and their capacity to carry out everyday tasks as well as on their families’ quality of life.

In a study including 73 meta-analyses and 8,601 unique articles, sugar consumption was associated with 18 endocrine/metabolic outcomes, 10 cardiovascular outcomes, seven cancer outcomes, and 10 other outcomes. Endocrine/metabolic outcomes included weight gain, ectopic fat accumulation, obesity, and cardiovascular disease, which were largely attributed to excessive consumption of fructose containing sugars.

In this meta analysis of 40 eligible trials involving 35,548 participants and seven diet programs, only the Mediterranean and low-fat diet showed effectiveness in in lowering all cause and CV mortality. Notably, their preventive value increased with increasing CV risk. Diets (with number of studies) included in the meta-analysis:

In a study of patients with DM2, 75 years old and over, continuous glucose monitoring revealed that 65% had glucose level two times below range (<54 mg/dL during ≥15 consecutive minutes) between midnight and 6 a.m. Fewer than half of the patients detected the hypoglycemic episode via self-monitoring. Because hypoglycemia episodes are associated with long-term complications, continuous glucose monitoring (CGM) could be used to improve care in these patients.

Comparing outcomes for all available monoclonal antibody treatments for COVID, this study found the risk for hospitalization or death at 28 days was 4.6% in treated patients and 7.6% in nontreated control patients. Relative risk was somewhat lower for Alpha and Delta variants, and highest for Omicron variants.

The study authors highlight that buprenorphine can be safely started in an emergency department without triggering withdrawal, even among individuals who use stronger opioids like fentanyl. They note, “this study provides further evidence that all emergency department physicians can and should be using buprenorphine to help individuals take the first steps into treatment and toward recovery.”