Articles related to CLINICAL STUDY

The authors evaluated the treatment approaches and outcomes of 110 patients with primary plasma cell leukemia (pPCL) in this retrospective study . Higher complete response rates were associated with treatment with bortezomib, lenalidomide, and dexamethasone (VRd) or daratumumab-based quadruplets (DBQ) and autologous stem-cell transplantation. Patients who received VRd/DBQ had better outcomes than those who received other bortezomib-based combinations or standard chemotherapy.

According to the findings of this study, patients with rectal cancer who were monitored using a watch-and-wait approach had a good quality of life, with some patients reporting bowel and sexual dysfunction. When patients needed surgery, their quality of life and functional outcome deteriorated. These findings will be useful in daily practice to advise patients on what to expect from a wait-and-see approach.

Danish researchers assembled a prospective observational cohort study of 9,533 asymptomatic people aged 40 years or older with no known ischemic heart disease to define characteristics of subclinical coronary atherosclerosis associated with the development of myocardial infarction. The study’s findings are startling.

In a randomized controlled trial at three US hospitals over six months in 2021, the researchers randomized 30 attendings to prioritize seeing patients who were expected to be discharged that day before seeing other patients. Marisha Burden, MD, FACP, a professor of medicine and division head of hospital medicine at the University of Colorado School of Medicine in Aurora, and Angela Keniston, MSPH, an assistant professor and director of data and analytics for the division of hospital medicine at the University of Colorado School of Medicine, discuss the study’s findings.

In a study of nearly 100,000 individuals aged 30 to 95 without any prior evidence of CVD, decline in peak metabolic equivalent of task score (METS) of greater than 1.0 was inversely proportionate to changes in mortality risk. METS were determined using symptom-limited exercise treadmill tests.

Originally published in JAMA Psychiatry, a broad-based study shows nearly 7% of OUD patients are adding buprenorphine to urine sample to fake treatment adherence. Buprenorphine spiking suggests to the physician that the treatment plan is not working—especially in patients continuing illicit drug use.