Articles related to CLINICAL STUDY

A study using Medicare claims data examined racial and ethnic disparities in the use of medications for opioid use disorder (OUD) among fee-for-service beneficiaries in the United States. The study found that after an OUD-related event, such as an overdose or hospitalization, Black patients had lower rates of receiving medications to treat OUD compared to White patients. In the 180 days following the index event, Black patients received buprenorphine after 12.7% of events, while Hispanic patients received it after 18.7% of events and White patients after 23.3% of events. Similar patterns were observed with naloxone and benzodiazepines. These racial and ethnic differences in medication receipt did not change significantly from 2016 to 2019, and all groups had multiple ambulatory visits despite the disparities. The study highlights substantial and persistent racial and ethnic disparities in accessing medications for OUD among Medicare beneficiaries with disability. Black patients, in particular, had lower rates of receiving medications compared to White patients. These disparities remained consistent over time, suggesting that efforts to improve equity in medication access for OUD are needed. The findings emphasize the need to address systemic barriers and biases in healthcare delivery to ensure equal access to evidence-based treatments for OUD among […]

In this study, of the 118 transgender and gender nonbinary (TGNB) patients, one-third of participants reported misgendering (being addressed in the dental environment using the wrong name and pronouns). Although refusal of oral health care was uncommon in our sample of TGNB participants, more than half believed that their regular source of oral health care was unable to provide gender-appropriate care. Avoidance owing to gender identity was found to be substantially related to self-reported unsatisfactory dental health. Gender insensitivity, awkward interactions, avoidance of care, and a lack of gender-affirming practitioners were all common themes un participants’ oral health care experiences.

Researchers discovered that among the 24,655 children aged between 6 months to 5 years examined, the overall prevalence of dental tooth decay, cavities, and toothaches was 9%. Dental illness was more common in children who had never been nursed (12.3%) and those who had public health insurance (14.3%). Children who were exclusively breastfed for 6 months, on the other hand, were shown to be 28% less likely to suffer dental tooth decay, cavities, or toothaches than children who were never breastfed.

Phosphodiesterase-5 inhibitors (PDE5i) have been found to reduce the risk of major adverse cardiovascular events in men with both coronary artery disease (CAD) and erectile dysfunction (ED), with tadalafil showing greater cardiac benefits compared to sildenafil, according to a study presented at the American Urological Association’s annual meeting. The retrospective study analyzed over 41,000 men with CAD and ED and found that those who took tadalafil or sildenafil had significantly lower 5-year risks of heart failure, myocardial infarction, and overall mortality compared to those who received no PDE5i treatment. Tadalafil recipients had even lower risks than sildenafil recipients across all categories. The study suggests that understanding the specific differences among PDE5i medications is crucial for addressing cardiac outcomes in patients with ED and CAD, with tadalafil potentially offering superior benefits due to differences in pharmacokinetics and longer duration of efficacy. However, further research is needed before definitive conclusions can be made regarding preferential prescription of tadalafil over other PDE5i medications.

The Eat, Sleep, Console care approach dramatically reduced the number of days before infants with newborn opioid withdrawal syndrome were medically ready for discharge when compared to conventional care, without worsening specified unfavorable outcomes.

Adding to the evidence that good nutrition supports healthy aging, this study shows that blood levels of certain saturated fatty acids, along with omega-6, -7 and -9 fatty acids, correlated with improved memory as well as larger frontal, temporal, parietal lobes.