Articles related to CLINICAL STUDY

A total of 35 status migrainosus patients were enrolled; 30 of them were female, and the average age was 39. Before the drugs were given, everyone’s serum magnesium levels were normal. There were no ECG alterations found, and none of the patients experienced any severe side effects either during or right away following the infusion. In 15 patients, there was a positive effect; in 10, there was no effect; and in 10, there were no data.

This report on learnings shows that it is crucial to educate primary healthcare professionals on how to spot people who may commit suicide in their later years (eg, using “The 5 Ds” — Deadly methods, Depression, Disease & Disability, Disconnectness, and Development) and how to adopt prevention measures.

Despite having anti-psychotic, anxiolytic, sedative, and hypnotic properties, quetiapine is linked to an increased risk of cardiovascular death and sudden cardiac death when used in conventional doses. For the first time, the current investigation demonstrated that quetiapine taken off-label and in modest doses raises the risk of major adverse cardiovascular events (MACE), stroke, and cardiovascular death.

SI, sadness, and anxiety symptoms could all be effectively treated with ketamine. The high rates of response and remission in population samples of TRD were comparable to those for interventional therapies. Racemic ketamine infusion as the main treatment for SI requires randomized controlled trials and comparative efficacy studies with other therapies.

A UK study reports that a history of irregular menstrual cycle was associated with higher risk for afib in women. A finding from the Vitamin D and Omega 3 Trial (VITAL) Rhythm Study reveals that when controlled for height and body size, women are at higher risk than men for afib, suggesting that biological sex and body size account for much of the protective effect of female sex. And as separately reported, early rhythm control is associated with lower risk for CV events as compared to usual care.

Exploring the Korean National Health Insurance claims database revealed that rhythm control via ablation or drugs, initiated within 1 year of diagnosis of AF, was associated with lower risk for cardiovascular events. This held true for both low risk and higher risk patients. The study analyzed data on more than 35,000 patients with a median age of 70.