Articles related to CLINICAL TRIALS

In a controlled trial conducted over a six-month period in Mali, subcutaneous administration of the monoclonal antibody L9LS to children aged 6 to 10 achieved an efficacy rate of up to 77% in preventing clinical malaria.

In a randomized trial involving over 500 preterm infants, researchers found that neither specialized amino acid solutions nor milk supplements significantly altered body composition at 4 months, suggesting that simpler feeding regimes may be equally effective.

A recent study highlights the efficacy of exagamglogene autotemcel, a CRISPR-Cas9 gene-edited therapy, in preventing severe vaso-occlusive crises in 97% of treated sickle cell disease patients over a 12-month period. This therapy not only promises reduced hospital visits but also sets a precedent in genetic treatments for hemoglobinopathies.

In the recent KEYNOTE-564 trial, adjuvant pembrolizumab therapy was shown to increase the 48-month overall survival rate to 91.2% compared to 86.0% with placebo among post-surgical patients with renal-cell carcinoma at increased risk of recurrence.

In this study, dostarlimab combined with carboplatin-paclitaxel demonstrated a marked improvement in progression-free and overall survival among endometrial cancer patients, particularly those with genetic markers for dMMR and MSI-H.

Reevaluating beta-blocker therapy post-myocardial infarction, a recent trial found no significant difference in the composite primary endpoint of death from any cause or new myocardial infarction between patients treated with long-term beta-blockers and those without.