Articles related to HYPERTENSION

Investigating a new frontier in hypertension treatment, this phase 1 study elucidates the efficacy and safety of zilebesiran, an RNA interference therapeutic agent. The study offers insights into dose-dependent effects and coadministration with existing hypertension medications, inviting further exploration in this vital area of medicine.

New findings suggest systolic blood pressure time in target range as a potential indicator for dementia risk, independent of mean SBP, underscoring the role of consistent blood pressure management in dementia prevention.

Examine the case of a young smoker with acute dyspnea whose chest CT reveals oddly shaped cysts to uncover a mystery that goes beyond usual diagnostics and leads us into the world of uncommon lung disorders.

In a randomized, double-blind, repeated crossover trial that involved almost 1,500 individuals with stage II hypertension, researchers found significant variation in individual responses to different antihypertensive treatments, particularly for lisinopril versus hydrochlorothiazide, lisinopril versus amlodipine, candesartan versus hydrochlorothiazide, and candesartan versus amlodipine. The study highlights the need for personalized antihypertensive therapy as there is substantial heterogeneity in blood pressure response to drug therapy for hypertension. The researchers recommend further studies to identify the mechanisms behind these individual differences to enable personalized antihypertensive therapy in routine clinical practice. This study’s findings underscore the importance of considering individualized treatment approaches for hypertension management to achieve optimal outcomes.

This 28-year-old man with hypertension and diabetes works two jobs, says he does not have time to exercise, takes most of his meals from fast-food restaurants, and is unhappy with his lifestyle. What would you recommend?

The patient’s ankylosing spondylitis is poorly controlled. He has avoided biologics and is on naproxen only. Now his course is complicated by persistent lower extremity edema. Other than hypertension, his vitals are normal. His spine is kyphotic with reduced mobility. He has 2+ swelling in both legs. After reviewing the labs, suggest your diagnosis.