Articles related to RESEARCH & CLINICAL TRIALS

The study reveals that 10% of patients treated with eli-cel developed hematologic cancer, with an incidence rate of 2.1 per 100 person-years. This finding emphasizes the need for careful monitoring and risk assessment in gene therapy approaches.

The study’s findings highlight the complex interplay between CAR T cell therapy and cytokine signaling in AML treatment, suggesting new avenues for improving outcomes in this challenging disease.

In a population-based trial, MRI-targeted biopsy significantly reduced the detection of clinically insignificant prostate cancer compared to systematic biopsy, without increasing the risk of advanced cancer detection. These findings support the use of MRI-targeted biopsy as a more efficient and safer screening method.

The ABYSS trial questions the safety of interrupting long-term beta-blocker treatment in patients with a history of uncomplicated myocardial infarction, finding that discontinuation was not noninferior to continuation.

The trial found no significant difference in hospitalization or death risk between patients using long-term oxygen therapy for 24 hours versus 15 hours per day, potentially offering more freedom for those with severe hypoxemia.

The Epitomee capsule, a novel ingestible device for weight management, has shown promising results in clinical trials, with 55.5% of users losing at least 5% of their baseline body weight at 24 weeks.