Articles related to TRANSPLANT MEDICINE

This 62-year-old man had a lung transplant 3 years previously for IPF and is on tacrolimus, mycophenolate, and prednisone. Which therapy is most appropriate for their zoster outbreak? IV acyclovir Oral famciclovir Oral valacyclovir Herpes zoster vaccine

Are the findings a result of bacterial endocarditis? Resurgent sarcoidosis? An opportunistic fungal pulmonary invasion? Review the workup and cast your vote on what you think the diagnosis is.

The story of David Bennett, age 57, who had severe cardiac failure and was denied a traditional human heart transplant from several programs when he ultimately agreed to the experimental xenotransplant. On day 34, the patient showed no signs of rejection of the porcine heart, but by day 49, sudden diastolic thickening and antibody-mediated failure of the xenograft prevented any lifesaving measures, and he died on day 60.

Dr. Mohyudding summarizes key findings ASCO reports, including updates on teclistamab in CAR-T, the DETERMINATION trial assessing auto-transplantation, cilta-cel (covered by HCN here), and the ATLAS study evaluating carfilzomib with lenalidomide and dexamethasone as maintenance vs. lenalidomide alone.

Responses to conventional donor lymphocyte infusion for post-allogeneic hematopoietic cell transplantation relapse are typically poor. Natural killer cell-based therapy is a promising modality to treat post-HCT relapse. This ongoing phase I trial of adoptively transferred cytokine induced memory-like (CIML) NK cells in patients with myeloid malignancies relapsed after haploidentical HCT saw a dynamic evolution of the activated CIML NK cell phenotype, superimposed on the natural variation in donor NK cell repertoires.

This meta-analysis examined 1,212 published articles and abstracts, of which the 30 fulfilling their criteria were analyzed to evaluate the effect of vitamin D levels on OS, PFS, and secondarily on time to treatment, relapse rate, and non-relapse mortality in patients with hematologic malignancies. Lower vitamin D level at diagnosis was related to a significantly impaired prognosis for myeloid and lymphoid malignancies, as previously reported.