In conclusion, daratumumab (Darzalex) (D) was added to lenalidomide, bortezomib, and dexamethasone (RVd) in NDMM patients who were transplant-eligible, and this led to enhanced stringent complete response (sCR) and minimal residual disease (MRD)-negative rates, a tolerable safety profile, and no clinically meaningful effects on stem cell mobilization or engraftment. These findings suggest that the D-RVd combination may become a new standard of care for NDMM who are transplant-eligible.

Acquired/congenital bone marrow failure, thalassemia/hemoglobinopathies, transfusion medicine, new therapies (pharmacology), infections of the immunocompromised, hematologic malignancies (acute/chronic leukemias; myeloma/lymphomas), thoracic oncology (head/neck/lung/thyroid), and many other practice improvement areas are covered in this CME activity worth up to 41.25 credits. The video curriculum starts at $1,795 in price.

Greater adherence to a number of healthy eating patterns was linked to a lower risk of death in this cohort study, which included 44,085 men and 75,230 women from the Health Professionals Follow-Up Study (1986-2020) and the Nurses’ Health Study (1984-2020). These relationships held true for persons who were Hispanic, non-Hispanic Black, and non-Hispanic White, as well as for other racial and ethnic groupings.

Shortness of breath and a cough were the first symptoms that were frequently recorded at the beginning of the pandemic, followed by vascular damage. Since then, there has been a change in symptom clusters and symptoms among the variants, which has been influenced by the virus’s evolution as well as vaccinations, the landscape of vaccines, the use of other treatments, and patients who experience recurring infections. The way that symptoms manifest has changed because to vaccination, acquired protection from earlier infections, and the evolution of omicron to cause generally less severe acute infections. Currently, the majority of the symptoms that doctors are observing are upper respiratory symptoms, such as coughing, sneezing, and sore throat.

According to a University of Washington research, only 40% of rural counties nationally had at least one licensed physician who could prescribe buprenorphine in 2016. The analysis discovered that by 2020, that number had increased to 63%. The increase was attributed by the study to modifications in federal regulations that permit NPs, PAs, and other healthcare professionals to prescribe buprenorphine. Only doctors could perform this in the past, and many remote counties lacked any. In 2002, Suboxone received approval from federal regulators, providing a new option for addiction treatment in communities without methadone facilities. Marshalltown, a town of 27,000 people encircled by rural areas, offers a feasible alternative, according to Andrea Storjohann, NP.

Adjuvant olaparib (Lynparza) was linked with significantly longer life free of invasive or distant illness compared to placebo among patients with high-risk, HER2-negative early breast cancer and germline BRCA1 or BRCA2 pathogenic or possibly pathogenic mutations. Global patient-reported quality of life was not significantly impacted by olaparib.