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Annals of Internal MedicineAllopurinol Initiation and All-Cause Mortality Among Patients With Gout and Concurrent Chronic Kidney Disease

In contradistinction to recent reports that showed increased risk of death and no clinical benefit with escalation of allopurinol for progressive CKD, this 5-year population-based review found no increased mortality risk in escalating allopurinol dose and achieving target serum urate levels.

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