Articles related to CLINICAL STUDY

Comparing outcomes for all available monoclonal antibody treatments for COVID, this study found the risk for hospitalization or death at 28 days was 4.6% in treated patients and 7.6% in nontreated control patients. Relative risk was somewhat lower for Alpha and Delta variants, and highest for Omicron variants.

The study authors highlight that buprenorphine can be safely started in an emergency department without triggering withdrawal, even among individuals who use stronger opioids like fentanyl. They note, “this study provides further evidence that all emergency department physicians can and should be using buprenorphine to help individuals take the first steps into treatment and toward recovery.”

Frequent use of prescription meds for sleep carries an increased risk for dementia in White older adults compared with those who rarely or never used them, as described in the January issue of Journal of Alzheimer’s Disease. The study found no increased risk for dementia for those who took sleep medications “sometimes.”

The authors evaluated the treatment approaches and outcomes of 110 patients with primary plasma cell leukemia (pPCL) in this retrospective study . Higher complete response rates were associated with treatment with bortezomib, lenalidomide, and dexamethasone (VRd) or daratumumab-based quadruplets (DBQ) and autologous stem-cell transplantation. Patients who received VRd/DBQ had better outcomes than those who received other bortezomib-based combinations or standard chemotherapy.

According to the findings of this study, patients with rectal cancer who were monitored using a watch-and-wait approach had a good quality of life, with some patients reporting bowel and sexual dysfunction. When patients needed surgery, their quality of life and functional outcome deteriorated. These findings will be useful in daily practice to advise patients on what to expect from a wait-and-see approach.

Danish researchers assembled a prospective observational cohort study of 9,533 asymptomatic people aged 40 years or older with no known ischemic heart disease to define characteristics of subclinical coronary atherosclerosis associated with the development of myocardial infarction. The study’s findings are startling.