Articles related to DEPRESSION

The author concludes that “careful use of T3  and L-T4  can be critical mood-stabilizingoptions, especially for depressive illness that has not responded to first-line therapies,and can provide an alternative to other augmentation strategies such as atypicalantipsychotics, lithium, or esketamine/ketamine.”

In this study enrolling 478 young adults, of which 265 self-reported anxiety and 146 self-reported depression, high-dose vitamin B6 supplementation raised brain GABA levelsand reduced self-reported anxiety.

In what is thought to be the largest study to date of any type of ketamine treatment, the findings revealed that, after four sessions, 89 percent of participants reported improvement in their depression and/or anxiety symptoms. On the PHQ-9 or GAD-7 scale, 63 percent of participants saw a 50% or greater improvement. PHQ-9 remission rates were 32.6 percent and GAD-7 remission rates were 31.3 percent. Furthermore, at the end of the four weeks, 62 percent of patients who had suicidal ideation prior to treatment reported no suicidal ideation.

Study: This meta-analysis includes 232 randomized, double-blind, placebo-controlled trials of drug monotherapy for major depressive disorder submitted to the FDA between 1979 and 2016, and comprises nearly 75,000 adult and child participants. Conclusion: Patients with depression are likely to improve substantially from acute treatment of their depression with drug or placebo. Although the mean effect of antidepressants is only a small improvement over placebo, the effect of active drug seems to increase the probability that any patient will benefit substantially from treatment by about 15%.

Kar-XT adds trospium to xanomeline to substantially improve the second agent’s tolerability, enabling its use to reduce both positive and negative symptoms in schizophrenia. Allopregnanolone, an oral version of brexanolone, is being investigated in MDD. The dextromethorphan and bupropion combo, AXS-05, seeks to offer a new antidepressant option and hydroxynorketamine promises MDD treatment without ketamine’s dissociative effects and abuse potential.

Anxiety disorders are among the most common of psychiatric disorders, with estimates suggesting a lifetime prevalence in the US of approximately 32%. But development of new and effective treatments for anxiety disorders has lagged behind new treatments for other conditions such as major depressive disorder, bipolar disorder, and schizophrenia. This article reviews current treatment and their effectiveness, and highlights the emerging new hopefuls.