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The New England Journal of Medicine
A phase 3, multicenter, double-blind, randomized, placebo-controlled trial was conducted to evaluate the efficacy and safety of epicutaneous immunotherapy with a peanut patch in children aged 1 to 3 years with peanut allergy. No approved treatment for peanut allergy exists for children under 4 years old. Participants with confirmed peanut allergy were assigned to either receive the peanut patch or a placebo daily for 12 months. The primary endpoint was the treatment response measured by the eliciting dose of peanut protein at 12 months. The trial showed that 67.0% of children in the intervention group demonstrated a treatment response compared to 33.5% in the placebo group. Adverse events occurred in both groups, with serious adverse events and anaphylaxis observed more frequently in the intervention group. However, serious treatment-related adverse events were rare. In conclusion, this trial demonstrated that epicutaneous immunotherapy with a peanut patch for 12 months was more effective than placebo in desensitizing children aged 1 to 3 years with peanut allergy and increasing their tolerance to peanut protein. Although adverse events were observed in both groups, serious treatment-related adverse events were uncommon. These findings suggest that epicutaneous immunotherapy may be a potential treatment option for young children with […]
Allergy & Immunology May 18th 2023
Hematology Advisor
Nutritional challenges are common in older adults with acute leukemia (AML/MDS), and can have a significant impact on their quality of life and treatment outcomes. These challenges can be caused by a variety of factors, including the disease itself, its treatment, and the normal aging process. Some of the most common nutritional challenges in older adults with AML/MDS include appetite loss, weight loss, diarrhea, constipation, and mouth sores; physicians can provide nutritional interventions to help address these challenges and improve the quality of life for older adults with AML/MDS. These interventions may include nutrition counseling, meal planning, supplementation, and enteral nutrition.
Geriatrics May 16th 2023
MDLinx
Combining alcohol and caffeine is more likely to cause drinkers to underestimate their level of intoxication. The practice among young people leads to more reports of unprotected or unwanted sex, DUI, riding with intoxicated drives, and alcohol-related injury. The combination can also increase blood pressure, raising the risk of stroke and heart attack in at-risk populations.
All Specialties May 9th 2023
Adding to the evidence that good nutrition supports healthy aging, this study shows that blood levels of certain saturated fatty acids, along with omega-6, -7 and -9 fatty acids, correlated with improved memory as well as larger frontal, temporal, parietal lobes.
Endocrinology, Diabetes, Metabolism May 9th 2023
As published in Cochrane Reviews, cranberry products reduce the risk of repeat symptomatic UTIs in women by more than a quarter. In children and individuals susceptible to UTI following medical interventions, the risk reduction is greater than 50%.
Family Medicine/General Practice May 3rd 2023
According to a new review, eating mushrooms may lower your risk of developing stomach cancer, and the benefits may be due to the fungi’s useful characteristics. To determine the connection between mushroom consumption and gastric cancer risk, the review examined the findings of a meta-analysis of previously published studies and the Stomach Cancer Pooling (StoP) Project. It was discovered that “higher mushroom consumption was associated with a lower risk of gastric cancer.” Eleven studies totaling 3,900 cases of stomach cancer and 7,792 control cases made up the StoP Project. Through questionnaires about food consumption, the mushrooms of study participants were assessed. Participants who consumed the most mushrooms compared to those who ate the fewest mushrooms had a relative risk (RR) of gastric cancer of 0.82. The researchers present a plausable analysis, but more research is needed to confirm if eating mushrooms truly reduces gastric cancer risks and, if so, why.
Oncology, Medical May 1st 2023