Articles related to PARKINSON'S DISEASE (PD)

Explore the new era of Parkinson’s disease treatment with the Cala kIQ System, a wearable, FDA-approved device designed to control action tremors by emulating the principles of deep brain stimulation.

Uncover the potential link between antiepileptic drug use and Parkinson’s disease incidence; join the discussion to decipher the results of this groundbreaking case-control study and explore the future of epilepsy treatment.

Dopaminergic Dysfunction: A Key Player in Parkinson’s Disease Motivational Symptoms This study reveals a significant link between dopaminergic dysfunction and the emergence of motivational symptoms in Parkinson’s disease. Striatal DAT imaging emerges as a potential tool for predicting apathy/anhedonia risk, opening new avenues for intervention strategies.

The investigational combination therapy of extended-release pramipexole and extended-release rasagiline controlled symptoms similar to pramipexole alone in this phase 3 trial, but with less sleepiness and orthostatic hypotension. Pramipexole mimics dopamine activity in the brain, and rasagiline increases dopamine levels by blocking dopamine reuptake.

New findings from an open-label clinical trial show that by 12 weeks into the maintenance phase, daily off time had decreased by an average of about three hours. Daily “good on” time consistently increased by an average of three hours per day when symptoms are under control without bothersome dyskinesia. By week 12, 62.1% had less free time—at least two hours less per day. The amount of levodopa taken on average every day during the research significantly decreased, which was consistent with improved symptom control. At week 12, just over two-thirds (65%) of patients said they had “much improved” or “very much improved” since beginning SPN-830. Patients reported that their overall health had improved by about 90%.

In this study, current coffee consumers had a significantly lower volume across striatal regions versus non-consumers. There was also evidence that cessation of coffee drinking led to increase and normalization of striatal volume over time.