New findings from an open-label clinical trial show that by 12 weeks into the maintenance phase, daily off time had decreased by an average of about three hours. Daily “good on” time consistently increased by an average of three hours per day when symptoms are under control without bothersome dyskinesia. By week 12, 62.1% had less free time—at least two hours less per day. The amount of levodopa taken on average every day during the research significantly decreased, which was consistent with improved symptom control. At week 12, just over two-thirds (65%) of patients said they had “much improved” or “very much improved” since beginning SPN-830. Patients reported that their overall health had improved by about 90%.

Disability and quality of life results were comparable between decompressive craniectomy and craniotomy in individuals with traumatic acute subdural hematoma. More people in the craniotomy group underwent additional surgery, although the craniectomy group experienced more wound issues.

Based on previously found and published population pharmacokinetic models, Monte Carlo simulation was used to investigate corrective dosing regimens. The delayed time, predetermined dose interval, and half-life of the antiseizure medicine were strongly linked with the suggested treatment regimens. Additionally, there were differences between the best treatment plans for adult and pediatric patients. The treatment plans may also be influenced by renal function and concurrent medications that affect the antiseizure drug’s clearance. A user-defined module with all parameters that could be configured flexibly by the user was also established in order to provide tailored remedial regimens for the delayed or missing dose. Both of these tools are web-based dashboards.

Advancing kidney health. Nanoscience. Bioanalytics. Biomaterials. Fighting pediatric leukemias. What’s the common thread? They describe the areas of research focus for four electees to AAAS this year.

Not all plastic surgeries can be reversed, and even when possible, reversals aren’t guaranteed. The Brazilian Butt Lift is an example of one surgery that appears to be going out to style. Similarly, the acceleration of surgeries for body dysmorphic disorder opens other reversal questions.

In this study, participants with OCD were seen to have a complex imbalance affecting the brain pathways and regions that are linked to emotion regulation and reward. The findings point to better targets for drug therapy since current medications interventions fail to benefit many OCD sufferers.