Previously untreated patients in this phase III research receiving enzalutamide with or without abiraterone acetate and prednisone (AAP) were being treated for metastatic castration-resistant prostate cancer (mCRPC). Median overall survival (OS), the main outcome, did not differ statistically between the two groups. Enzalutamide plus AAP, however, resulted in a longer radiographic progression-free survival (rPFS) than enzalutamide alone. Abiraterone clearance was two to three times higher when administered with enzalutamide than when given alone, according to pharmacokinetic studies. In the combo arm, there were more high-grade adverse events, such as atrial fibrillation, transaminitis, hypertension, and fatigue. Patients with mCRPC did not have their OS lengthened by the addition of AAP to enzalutamide, and the authors theorize that this may have been due to the combination arm’s higher abiraterone clearance.

This course is intended to provide information from an unbiased viewpoint on managing headaches while treating Chiari malformation with either medication or surgical therapy. This course will combine lectures, patient insights, and expert panels. It will be offered in person, digitally through Microsoft Teams, and on-demand for all paid attendees for one month following the conference. After completing this course, participants will be able to identify more precise headache care techniques and understand when surgery is necessary, use logic and reason when treating patients with Chiari malformation and headaches, and determine the prevalence of headaches and Chiari malformation in the general population.

The phase 2 L-MIND trial presented at the AACR 2023 conference showed that tafasitamab plus lenalidomide and tafasitamab maintenance resulted in durable responses for patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL). The trial treated patients with DLBCL who were not eligible for an autologous stem cell transplant with tafasitamab plus lenalidomide for 12 cycles, followed by tafasitamab alone until disease progression. With a median of 44 months of follow-up for the entire cohort, the objective response rate (ORR) was 57.5%. The ORR was higher among patients who had received only one prior line of therapy at 67.5%, whereas 47.5% of patients who had received multiple prior lines of treatment experienced a response. The complete response rate was 41.3% overall, with the median duration of response (DOR) not reached in all cohorts. The median progression-free survival (PFS) was 11.6 months for the entire cohort, while the median PFS of the cohort with one prior line of therapy was 23.5 months, whereas patients with multiple prior lines of therapy demonstrated a median PFS of 7.6 months. The frequency of treatment-emergent adverse events (TEAEs) decreased over time, and diarrhea and peripheral edema were the most common TEAEs during the initial treatment period […]

When body mass index (BMI) at the time of recruitment was taken into account in this case-control study, an inverse correlation between being overweight and the risk of CRC was found. However, when looking at BMI at earlier times, a clear positive association between BMI and CRC risk emerged, which was especially pronounced for BMI eight or more years ago. Recent weight loss was also strongly associated with increased CRC risk.

The 2023 AACR meeting has seen a large number of clinical abstracts presented, demonstrating that science from the lab is moving to the clinic. Examples include an RNA vaccine from Moderna in combination with pembrolizumab in a neoadjuvant setting in patients with melanoma, and the AEGEAN trial, which looks at perioperative therapy in patients with lung cancer. The conference is also seeing a focus on more diverse speakers, including junior investigators. The field of mRNA cancer vaccines is evolving, with personalised vaccines being used to activate the immune system in combination with checkpoint inhibitors, resulting in positive results in some cancers. The conference is an opportunity to learn about new science, make new connections and collaborations, and gain a better understanding of how to push the field forward.

According to a new review, eating mushrooms may lower your risk of developing stomach cancer, and the benefits may be due to the fungi’s useful characteristics. To determine the connection between mushroom consumption and gastric cancer risk, the review examined the findings of a meta-analysis of previously published studies and the Stomach Cancer Pooling (StoP) Project. It was discovered that “higher mushroom consumption was associated with a lower risk of gastric cancer.” Eleven studies totaling 3,900 cases of stomach cancer and 7,792 control cases made up the StoP Project. Through questionnaires about food consumption, the mushrooms of study participants were assessed. Participants who consumed the most mushrooms compared to those who ate the fewest mushrooms had a relative risk (RR) of gastric cancer of 0.82. The researchers present a plausable analysis, but more research is needed to confirm if eating mushrooms truly reduces gastric cancer risks and, if so, why.