Medical XpressHigh-potency Cannabis Use is Tied to Epigenetic Changes, Study Suggests

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A new study published in Molecular Psychiatry provides evidence that high-potency cannabis use is associated with distinct epigenetic changes. The research, conducted by King’s College London and the University of Exeter, offers insights into the biological impact of cannabis use, particularly its effects on DNA methylation.

Key Points:

• The study is the first to suggest that high-potency cannabis (≥10% THC) leaves a unique signature on DNA.
• Researchers analyzed DNA methylation across the human genome using blood samples from 682 participants, including those with first-episode psychosis and healthy controls.
• Frequent users of high-potency cannabis showed changes in genes related to mitochondrial and immune function, particularly the CAVIN1 gene.
• The epigenetic changes were not attributed to tobacco use, which is often mixed with cannabis.
• DNA methylation patterns differed between cannabis users experiencing their first episode of psychosis and users without psychosis.
• The study included participants from multiple European countries and Brazil, with an average age of first cannabis use at 16 years old.
• Researchers suggest the potential for DNA blood tests to help identify cannabis users at risk of developing psychosis.

“Our findings provide important insights into how cannabis use may alter biological processes. DNA methylation, which bridges the gap between genetics and environmental factors, is a key mechanism that allows external influences, such as substance use, to impact gene activity. These epigenetic changes, shaped by lifestyle and exposures, offer a valuable perspective on how cannabis use may influence mental health through biological pathways.”
– Dr. Emma Dempster, Senior Lecturer at the University of Exeter and the study’s first author

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