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ACP InternistACP’s Updated Depression Guideline Recommends CBT, Second-generation Antidepressants

The updated guidelines recommend, in brief:

  • Either cognitive behavioral therapy (CBT) or second-generation antidepressants (SGAs) as first-line monotherapy in the acute phase
  • Combination of both therapies in the acute phase as a third choice
  • CBT monotherapy in the acute phase of mild MDD
  • In non-responding patients on SGAs, add or change to CBT, change SGA, or add a second drug
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