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British Medical JournalEfficacy, Safety, and Tolerability of Antidepressants for Pain in Adults: Overview of Systematic Reviews

In an analysis of 26 reviews covering 8 antidepressant classes and 22 pain conditions, no review provided a high level of evidence for the effectiveness of antidepressants for chronic pain. The strongest evidence may be for SNRIs for back pain, postoperative pain, neuropathic pain, and fibromyalgia.

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