Verywell HealthResearch Shows a Popular Anti-Aging Supplement May Lower Blood Pressure

A meta-analysis of small randomized trials suggests NMN supplementation may slightly reduce blood pressure, particularly in adults over 60, though effects are much smaller than established interventions.

Editorial Note: This article summarizes an early clinical signal from small, short‑term studies. Observed blood‑pressure changes are modest and do not replace established lifestyle or pharmacologic hypertension management.

Clinical Considerations

• Diastolic reductions average ~2 mmHg.
• Systolic benefit is inconsistent.
• No cardiovascular outcome data are available.
• Lifestyle and medications remain superior.

Practice Applications

• Set expectations around modest effect size.
• Reinforce DASH diet, exercise, and medications as first-line.
• Prepare for supplement-driven patient questions.
• Coordinate discussions across care teams.

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