Articles related to BLEEDING/BLOOD DISORDERS

Discover the potential of prehospital interventions, specifically the administration of tranexamic acid, on the functional outcomes of adults with major trauma suspected of trauma-induced coagulopathy.

Discover how the topical application of 1:1000 adrenaline could revolutionize your approach to managing bleeding in oral surgery and dentistry, potentially improving surgical outcomes and patient experiences.

The surprising association between CHIP and a lowered risk of Alzheimer’s disease offers a novel perspective in our understanding of neurodegenerative disorders and paves the way for potential future therapeutics.

The Low-PV phase 2 trial provides compelling evidence for the use of ropeginterferon alfa-2b in the management of low-risk Polycythemia vera, demonstrating its superiority over the standard treatment of therapeutic phlebotomy and aspirin in maintaining hematocrit levels and reducing disease-related symptoms.

Unfolding a Clinical Enigma: From a Tibia Fracture in Congo to Mysterious Symptoms A Case Challenge study of a 58-year-old female who, after sustaining a tibia fracture in the Democratic Republic of Congo (DRC), started experiencing persistent fatigue, abdominal bloating, and elevated eosinophil counts, ignites a journey into the intricacies of infectious disease diagnosis and management. After reading, what’s your diagnosis?

Enhancing Platelet Dysfunction Diagnosis with Platelet Function Screen The Platelet Function Screen (PFA-100®) is a critical in vitro system for detecting platelet dysfunction. It uses citrated whole blood samples under high shear flow conditions, demonstrating its sensitivity. As blood is aspirated through collagen-coated membranes, platelet adhesion forms an initial matrix. Adding to the mix, platelet aggregation is stimulated by either epinephrine (COL/EPI) or adenosine diphosphate (COL/ADP), coating the membranes. In this process, the time required to form a platelet plug that blocks the aperture, known as closure time (CT), is the key measure of platelet function. Interestingly, several conditions can cause prolonged CT, including drug effects, low hematocrit, thrombocytopenia, von Willebrand Disease (vWD), and platelet disorders. Notably, aspirin therapy impacts the COL/EPI closure time more than COL/ADP. While assessing results, hematological considerations are pivotal, particularly with anemia and thrombocytopenia that could extend CT. Platelet counts below 150,000/uL or hematocrit below 35% could interfere with the results, thus, the test might not serve patients with counts below 100,000/uL or hematocrit under 30%. Moreover, hematocrit over 50% could generate inconsistent outcomes. Fundamentally, normal CT with both COL/EPI and COL/ADP signifies healthy platelet function. The COL/EPI membrane, while sensitive to primary hemostasis disorders, […]