Articles related to BONE HEALTH

IL-1B significantly influences breast cancer bone metastasis by promoting EMT, enhancing osteoclast activity, and creating a conducive metastatic niche. Targeting IL-1B in combination with standard therapies shows promising potential to reduce metastatic outgrowth.

Vitamin D supplementation requires careful management to achieve and maintain optimal serum 25(OH)D levels, particularly in populations at risk for deficiency and those with absorption issues.

In a longitudinal assessment spanning over two decades, researchers found that calcium and vitamin D supplementation in postmenopausal women contributed to a 7% reduction in cancer mortality.

In postmenopausal women, calcium and vitamin D supplementation is a double-edged sword, offering protection against cancer while potentially increasing cardiovascular risk. A nuanced approach to patient consultation is vital to navigate these contrasting outcomes.

In a rigorously designed trial involving more than 5,000 participants, researchers observed that testosterone treatment in hypogonadal men aged 45-80 was associated with a 1.43 times higher risk of clinical fractures compared to placebo. These findings are crucial in re-evaluating the therapeutic approach to testosterone replacement in this demographic.

This case study illuminates the risks of delayed diagnosis and treatment of Brodie abscess, particularly in the elderly, and underscores the importance of timely intervention to prevent severe complications.