Articles related to BONE HEALTH

Convincing bone loss would be bone loss at more than 1 site or over more than 1 interval, or bone loss associated with elevated markers of bone turnover such as cross-linked C-telopeptide of type-1 collagen (CTx) greater than 300 pg/mL.

Chronic daily ingestion of preformed vitamin A above the recommended intake but below the tolerable upper intake may still be harmful, especially to the musculoskeletal system.

Extraosseous calcification in chronic and end-stage kidney disease involves a complex pathogenesis, impacting patient morbidity and mortality through vascular, soft tissue, and calciphylaxis manifestations.

IL-1B significantly influences breast cancer bone metastasis by promoting EMT, enhancing osteoclast activity, and creating a conducive metastatic niche. Targeting IL-1B in combination with standard therapies shows promising potential to reduce metastatic outgrowth.

Vitamin D supplementation requires careful management to achieve and maintain optimal serum 25(OH)D levels, particularly in populations at risk for deficiency and those with absorption issues.

In a longitudinal assessment spanning over two decades, researchers found that calcium and vitamin D supplementation in postmenopausal women contributed to a 7% reduction in cancer mortality.