Articles related to CLINICAL STUDY

This study of 2,500 adults receiving mechanical ventilation randomized 1/3 were assigned to an exigent saturation target pf 90%, 1/3 to a target of 94%, and 1/3 to a target of 98%. The median number of ventilator-free days was 20, 21, and 21 for the three target groups, respectively. In-hospital death by day 28 was 34.8%, 34.0%, and 33.2% for the three groups, respectively.

The study’s findings offer a novel perspective on norepinephrine reuptake inhibitors’ impact on “upper airway stability during sleep and are significant to guide future pharmacotherapy development for OSA,” according to the authors. Additionally, the findings offer individuals who are unable to tolerate modern therapies, such as continuous positive airway pressure (CPAP) equipment, wider alternatives when seeking therapy for OSA.

A small group of patients (n=34) using opioids for fibromyalgia were randomized to wear green, blue, or unfiltered glasses for 4 hours per day for 2 weeks. There was no impact on pain scores. Those wearing green glasses trended (nonsignificantly) toward lower anxiety scores. The green glasses group did have lower opioid use.

At the time of this study, in 2016, dementia was seen in 10% of those over age 65 in the US, and mild cognitive impairment (MCI) in 20%, with increased risk for every 5 year advance in age. Risk was 80% higher for non-Hispanic Black individuals and approximately 40% higher in Hispanic persons, compared with White individuals. Dementia and MCI were inversely correlated with years of education, though.

In this randomized study of 1,000 patients with delirium admitted to the ICU, patients receiving haloperidol showed no significant difference in survival compared with patients who received placebo.

In this cohort analysis, which included male patients examined at 128 US Veterans Health Administration facilities between 2005 (n = 4,678,412) and 2019 (n = 5,371,701), facilities with greater rates of prostate-specific antigen screening showed lower rates of eventual metastatic prostate cancer incidence.