Articles related to CLINICAL STUDY

A detailed summarization of the clinical presentation of 197 individuals with PCR-confirmed diagnosis of monkeypox in the UK. The summary documents a highly variable prodrome in terms of prodromal symptoms and timing to eruption of visible lesions. Systemic illness was seen in 86% of patients. After mucocutaneous lesions, seen in 100% of patients, fever was the next most common manifestation, seen in 62% of patients.

“Eszopiclone and lemborexant work for insomnia despite adverse events, while prescription drugs such as benzodiazepines, daridorexant, suvorexant, and trazodone can be effective but are associated with poor tolerability, according to this systematic review and meta-analysis.”

An epigenetic inhibitor can boost immune system activity in patients with ovarian cancer, according to a Northwestern Medicine study published in the Journal of Clinical Investigation.

In this study of neoadjuvant chemotherapy with ruxolitinib, approximately 130 patients were randomized to receive dose-dense neoadjuvant chemotherapy with or without ruxolitinib, followed by interval debulking and finally three more cycles of dose-dense neoadjuvant chemotherapy with or without ruxolitinib. The ruxolitinib group experienced a 3-month difference in progression-free survival.

This interview reviews the implications of three recent studies — KEYNOTE-158, EMPOWER, KEYNOTE-826 — on immunotherapy in cervical cancer. In addition to the compelling connection between cervical cancer and the immune system, and therefore the interest in immunotherapy for cervical cancer, immunotherapy offers some key advantages over chemotherapy in this setting. It benefits patients with previous radiation as much as it benefits patients who are radiotherapy-naïve and it is less associated with the formation of fistulas than chemotherapy.

Higher levels of physical activity were associated with greater processing speed reserve in older women but not in older men, according to a recent study. This is good news, as dementia may be slowed by cognitive reserve, the capacity to maintain cognition in the face of brain damage. A cognitively active lifestyle that includes reading and information processing may delay the onset of dementia in Alzheimer’s disease by up to 5 years in persons in their 80s, according to recent research. Other research has suggested that cognitive reserve may be one factor in some centenarians’ ability to resist cognitive decline in the face of brain dysfunction.