Articles related to CLINICAL STUDY

Seven studies totaling 802 patients investigated the primary outcome of change in 100-point vertigo visual analog scale scores at around 2 hours following treatment with an antihistamine or benzodiazepine in this systematic review and meta-analysis of 1,586 participants within 17 trials. Antihistamines improved patients’ conditions more than benzodiazepines did (difference, 16.1), but they weren’t better than other active comparators such ondansetron, droperidol, metoclopramide, and piracetam.

The idea that depression is brought on by decreased serotonin activity or concentrations is unsupported, according to the authors of a systematic umbrella review, who also challenge the rationale behind the high rates of antidepressant prescription. They claim that certain medical professionals continue to promote the incorrect chemical imbalance explanation of depression, and the public as a whole still accepts it. However, other medical professionals argue that antidepressants continue to be a helpful treatment option for patients in addition to other methods like talking therapy and that the idea that depression is caused by a straightforward chemical imbalance is outdated in any case.

Many academic neurologists, especially younger faculty, are not fully aware that clinical service activities are the main source of medical school funding. The time for research and teaching has decreased, and transparent discussions of these problems and possible solutions are not common. This article strives to discuss the needed balance between education, clinical services, and advancing research.

Using covariate analysis of records from more than 1.2 million children over 17 years, these researchers conclude that the elevated risk for neonatal seizures and childhood epilepsy in children who were exposed to SSRIs or SNRIs during pregnancy can be attributed to the indicated SSRI and SNRI use for pregnant women, history of parental epilepsy, and other covariates, rather than the use of the medication itself.

From a cohort of approximately 21,000 people in the UK, alcohol consumption above about 4 drinks per week was associated with markers of higher brain iron in multiple basal ganglia regions, which was in turn associated with poorer scores on tests of executive function, fluid intelligence, and reaction speed.

The knee arthritis meta-analysis reviewed 169 trials involving 21,163 patients, with the evidence demonstrating viscosupplementation is associated with a clinically irrelevant reduction in pain intensity and with an increased risk of serious adverse events compared with placebo. For the meniscus study, the commentary may sum it up best: “Multiple studies, including several with sham surgeries as a control have shown repeatedly over the previous 2 decades that surgery is not superior to physical therapy, yet the issue and use of surgery persist.”