Articles related to CLINICAL STUDY

Guideline-directed binary distinctions between HER2-positive and HER2-negative breast cancer have guided physicians’ treatment decisions for quite some time, but new research suggests that patients with HER2-2+, ISH-negative breast cancer present a clinical picture closer to that of patients with HER2-positive breast cancer, offering up a new nomenclature, HER2-low.

A report from the European Alliance of Associations for Rheumatology (EULAR) annual meeting showed that, among 27 people with RA diagnoses, 13 had scores on the 14-item Changes in Sexual Functioning Questionnaire (CSFQ) in the range indicative of sexual dysfunction. In addition, the above was also true for 22 of 72 PsA patients.

Examining data on nearly half a million participants from the NIH-AARP Diet and Health Study revealed that individuals in the highest quintile of total fish intake had a 22% higher risk for malignant melanoma compared to those in the bottom quintile.

Giant cell arteritis (GCA) is one of the most dangerous rheumatologic conditions, and mortality rates among patients with the condition in Canada’s Ontario province has researchers very concerned without any explanation for the recent increases in mortality they documented. MedPage Today shares the report from Arthritis Care & Research.

The authors investigated the effect of adding radiotherapy to neoadjuvant chemotherapy on survival in patients with Stage III-N2 non-small cell lung cancer. Analysis included 1,175 patients diagnosed between 2004 and 2015; 799 (68.0%) underwent neoadjuvant CRT and 376 (32.0%) underwent neoadjuvant CT. Adding radiotherapy to chemotherapy showed a slightly higher median OS than chemotherapy alone (51 vs. 47 months, respectively), and a higher median CSS (75 vs. 59 months, respectively). However, these differences were not statistically significant.

The review, which we covered previously, concluded that “oral, synthetic cannabis products with high THC-to-CBD ratios and sublingual, extracted cannabis products with comparable THC-to-CBD ratios may be associated with short-term improvements in chronic pain and increased risk for dizziness and sedation.”