Articles related to CLINICAL STUDY

This interview reviews the implications of three recent studies — KEYNOTE-158, EMPOWER, KEYNOTE-826 — on immunotherapy in cervical cancer. In addition to the compelling connection between cervical cancer and the immune system, and therefore the interest in immunotherapy for cervical cancer, immunotherapy offers some key advantages over chemotherapy in this setting. It benefits patients with previous radiation as much as it benefits patients who are radiotherapy-naïve and it is less associated with the formation of fistulas than chemotherapy.

Higher levels of physical activity were associated with greater processing speed reserve in older women but not in older men, according to a recent study. This is good news, as dementia may be slowed by cognitive reserve, the capacity to maintain cognition in the face of brain damage. A cognitively active lifestyle that includes reading and information processing may delay the onset of dementia in Alzheimer’s disease by up to 5 years in persons in their 80s, according to recent research. Other research has suggested that cognitive reserve may be one factor in some centenarians’ ability to resist cognitive decline in the face of brain dysfunction.

Seven studies totaling 802 patients investigated the primary outcome of change in 100-point vertigo visual analog scale scores at around 2 hours following treatment with an antihistamine or benzodiazepine in this systematic review and meta-analysis of 1,586 participants within 17 trials. Antihistamines improved patients’ conditions more than benzodiazepines did (difference, 16.1), but they weren’t better than other active comparators such ondansetron, droperidol, metoclopramide, and piracetam.

The idea that depression is brought on by decreased serotonin activity or concentrations is unsupported, according to the authors of a systematic umbrella review, who also challenge the rationale behind the high rates of antidepressant prescription. They claim that certain medical professionals continue to promote the incorrect chemical imbalance explanation of depression, and the public as a whole still accepts it. However, other medical professionals argue that antidepressants continue to be a helpful treatment option for patients in addition to other methods like talking therapy and that the idea that depression is caused by a straightforward chemical imbalance is outdated in any case.

Many academic neurologists, especially younger faculty, are not fully aware that clinical service activities are the main source of medical school funding. The time for research and teaching has decreased, and transparent discussions of these problems and possible solutions are not common. This article strives to discuss the needed balance between education, clinical services, and advancing research.

Using covariate analysis of records from more than 1.2 million children over 17 years, these researchers conclude that the elevated risk for neonatal seizures and childhood epilepsy in children who were exposed to SSRIs or SNRIs during pregnancy can be attributed to the indicated SSRI and SNRI use for pregnant women, history of parental epilepsy, and other covariates, rather than the use of the medication itself.