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OBR Oncology
The NR2F1 gene normally prevents pre-malignant cells from spreading to other parts of the body. HER2 suppresses NR2F1, allowing pre-cancerous cells to move to other organs where they can become cancerous.
Oncology, Medical May 4th 2022
JAMA Network
In this case-control registry study of 63,828 patients with 14 common cancer types and 37,086 controls, pathogenic variants in BRCA1 were associated with biliary tract cancer, BRCA2 was associated with esophageal cancer, and combined BRCA1/2, with gastric cancer.
Oncology, Medical April 19th 2022
Journal of Clinical Oncology
PIK3CA is the most mutated oncogene across many of the common solid tumor types. Consequently, targeting PIK3CA has been of major clinical interest. Initial efforts at have not been promising, however. The limiting factors have primarily been lack of isoform specificity of inhibitors and dose-limiting toxicities. This study evaluates copanlisib, an α and δ isoform–specific phosphoinositide 3-kinase (PI3K) inhibitor, in patients with PIK3CA mutations.
Oncology, Medical February 15th 2022
A systematic review identified 204 eligible publications from 2000 through 2017, with much of the evidence consisting of systematic reviews of observational data, consensus guidelines, case series, and case reports. Due to the paucity of high-quality evidence on management of immune-related adverse events, recommendations are based on expert consensus.
Dermatology December 21st 2021
ASH Clinical News
The U.S. Food and Drug Administration (FDA) held a two-day public meeting to discuss managing the potential side effects of gene therapies following the death of a boy with a rare neuromuscular disease. High doses of gene therapies are known to cause liver damage, and recent studies have also found a potential long-term cancer risk in mice and dogs treated with gene therapies.
Hematology November 16th 2021
Dana-Farber Cancer Institute
Messenger RNA (mRNA) is in the spotlight right now as the basis of the Moderna and Pfizer/BioNTech vaccines for COVID-19. Thanks to this newfound prominence, its profile has been raised as a powerful tool in cancer research as well. As a courier of genetic information and protein assembler, mRNA can tell scientists which genes are active within a cell and produce the proteins that alert the immune system to the presence of cancer.
Hematology July 19th 2021