Articles related to GYNECOLOGICAL CANCERS

Selinexor has demonstrated an extraordinary extension in progression-free survival in patients with wild-type TP53 advanced or recurrent endometrial cancer, according to the recent findings from the SIENDO study.

Dr. Jyoti Mayadev, a professor of Radiation Medicine at University of California San Diego, discussed the treatment of patients with 1B3 cervical cancer at the Society of Gynecological Oncology’s Annual Meeting on Women’s Cancer. The discussion centered around whether to treat patients with primary chemoradiation and brachytherapy or radical surgery. Dr. Mayadev recommends a multidisciplinary approach, but notes that level 1 evidence data from Landoni et al. in 1997 showed no difference in progression-free survivals or overall survivals between radiation therapy and radical hysterectomy in patients with bulky disease, 1B3, and no lymph node disease. Dr. Mayadev discusses the benefits of chemoradiation, including potential toxicity reduction if a patient needs adjuvant therapy after surgery. She also notes that with technologically advanced radiation and brachytherapy, long-term toxicities can be minimized, including genitourinary toxicities at 6-8%, vaginal toxicities at 5%, and fistula at less than 2%. Dr. Mayadev believes that adaptive radiation therapy may further decrease toxicities and increase cure rates for patients with 1B3 cervical cancer. There are ongoing trials for novel therapeutics and adaptive radiation therapy, such as the ARTIA Cervical Trial, which aims to decrease toxicities and collect patient reported outcomes.

In this on-demand webinar, a trio of Roswell Park Comprehensive Cancer Center experts share their wisdom on ovarian, cervical, and endometrial cancers. Dr. Emese Zsiros, Chair of Gynecologic Oncology, hosts the event with presenters Drs. Karen McLean and Katherine LaVinge Mager, Associate Professor of Oncology and Assistant Professor of Oncology in the Department of Gynecologic Oncology, respectively.

Cancer Therapy Advisor provides a variety of resources, including regimens used to supplement the most recent treatment strategies. Examine all regimens here.

An ASCO Reading Room selection Fascinating work defining new therapeutic targets and cutting-edge treatment approaches in gynecological cancer is about to come. In this abstract, the authors go over new therapies for gynecologic cancers, such as endometrial, cervical, ovarian, and uncommon gynecologic tumors, and highlight studies that have improved clinicians’ knowledge of the distinct biology and molecular foundations of different tumors, which is being used to develop potent new therapeutic modalities.

In this study of neoadjuvant chemotherapy with ruxolitinib, approximately 130 patients were randomized to receive dose-dense neoadjuvant chemotherapy with or without ruxolitinib, followed by interval debulking and finally three more cycles of dose-dense neoadjuvant chemotherapy with or without ruxolitinib. The ruxolitinib group experienced a 3-month difference in progression-free survival.