Articles related to SCHIZOPHRENIA

Explore the complexities of recently found pathomechanisms, cutting-edge research on emergent molecular pathways, and thorough insights into novel treatment options.

This groundbreaking study from Northwestern Medicine unveils a surprising interaction of antipsychotic drugs with neurons, prompting a revision of our understanding of psychosis treatment and opening new pathways for more effective, safer drugs.

NEW YORK CITY | THE GLASSHOUSE CHELSEASATURDAY, JUNE 24, 2023 In a comprehensive in-person setting, psychiatrists will get current, clinically relevant, and practice-based updates. This full-day conference will feature interesting presentations conducted by renowned thought leaders in schizophrenia, postpartum depression, major depressive disorder, ADHD, and addiction. Each session will include a patient perspective to ensure professionals obtain practical, real-world understanding.

Poor adherence to treatment is the biggest predictor in relapse in serious mental illnesses. In this 0.5-CME credit activity, the panel discusses key contributors to the adherence challenge and strategies for improving adherence – including use of newer, better tolerated therapies. Available in video, podcast, and text.

Lumateperone 42 mg/d is effective in the treatment of schizophrenia and has no clinically significant effects on body weight, metabolic variables, motor function, the ECG QT interval, or prolactin levels, with a likelihood to be helped or harmed (LHH) much greater than 1 when comparing therapeutic response to these tolerability/safety outcomes. When comparing therapeutic response versus a somnolence/sedation AE, lumateperone appears to be associated with somnolence/sedation, and LHH approaches 1. In indirect comparisons with other antipsychotics, this somnolence/sedation AE profile is not dissimilar; however, the absence of weight gain, glucose/lipid abnormalities, and akathisia, as well as the absence of prolactin elevations, distinguishes lumateperone.

The development of effective new therapies has been challenging. This discovery of calcium signaling as a central abnormality in schizophrenia neurons is an exciting new finding, since available antipsychotics treat only positive symptoms and are not effective for all patients.