This international consortium of oncologists and researcher describe the advantages and limitations of both conventional chromosome banding and novel sequencing technologies. They state, “While one single test may not replace the totality of tests that currently exist, the active exploration and adoption of novel approaches in defined clinical settings may indeed allow for a continued and controlled evolution resulting in the successful clinical implementation of whole genome sequencing in the near future.”

Predictive biomarkers are needed to identify patients with oropharyngeal squamous cell carcinoma (OPSCC) that could enjoy treatment de-escalation, with the attendant reduction in incidence of acute and late toxicities. In an observational study of consecutive patients with patients with oropharyngeal squamous cell carcinoma, pretreatment absolute lymphocyte count was predictive for 5-year overall survival. It also predicted benefit from the use of concurrent cisplatin chemotherapy.

A 12-year odyssey of a cancer drug that works in a subcellular organelle: From discovery of a unique and promising tumor target – featured on the cover of the Journal of Clinical Investigation – through startup company, grant-writing, DoD funding, Wall Street disinterest, perseverance, and finally, approval to initiate clinical trials.

Follow this case study of a 71-year-old man found to have significant, asymptomatic hypokalemia discovered in routine outpatient lab work. How would you manage this patient?

Walking exercises have been found to improve outcomes for people suffering from peripheral artery disease (PAD). Specifically, among adults with PAD and intermittent claudication, a home-based, walking exercise behavior change intervention, compared with usual care, resulted in improved walking distance at three months. However, authors of the JAMA study concluded that further research is needed to determine the durability of these findings.

The Centers for Disease Control and Prevention (CDC) warns that the incidence of sexually transmitted diseases (STDs) in the US continued to rise during the first year of the pandemic. For the first time in seven years, the overall number of reported STD cases was lower than the previous year, but the CDC attributed the drop-off to a decline in reported cases of chlamydia — the nation’s most common STD — that was likely a result of pandemic-related interruptions to screening.