Articles related to Endocrinology, Diabetes, Metabolism

In the 5-year, multi-center, randomized, controlled GRADE trial (Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study), insulin glargine and liraglutide were about 13% more effective than glimepiride in keeping HbA1c lower than 7.0%, and 30% more effective than sitagliptin.

Because this GLP-1 agonist is known to reduce food intake, physicians have been prescribing tirzepatide off-label for weight loss for years. But unlike other drugs in its class, tirzepatide targets GLP-1 and GIP receptors.

Questions run across a host of topics, and in September you can challenge yourself in mortality risk, myocardial infarction (MI), insomnia, liver cancer, lipids, and Parkinson’s disease guidelines. Each question is worth 4 points with bonuses for quick response. Speed matters in this quiz. Why not give it a try and see if you can get on the leaderboard of the Smartest Doc?

The founding editor of Comprehensive Clinical Nephrology teases out for us our physiologic response to salt, sugar, fat, and water that creates a recipe for obesity – a recipe being used daily by many Americans with obvious results. His recommendation? “Drinking more water and reducing salt intake offer cheap, easy and healthy strategies that may prevent or treat obesity.” Click to see the evidence behind the conclusion.

This summary of a study from Johns Hopkins University says it might just matter how you take your pills – with special implications for bedridden or sedentary patients.

The authors engaged in research to attempt to identify circulating biomarkers for pancreatic NETs, to improve tumor surveillance and quality of life. They examined the expression of circulating miRNA in the serum of MEN1 patients and found an inverse relationship between miR-3156-5p and MORF4L2 expression, representing a potential serum biomarker that could facilitate the detection of NET occurrence in MEN1 patients.