Articles related to BRAIN INJURY/CONCUSSION

This review delves into the neurological consequences of preterm birth, highlighting the particular brain impairments and developmental obstacles that survivors experience. Learn about the most recent advances in advanced neuroimaging and potential treatments to improve outcomes.

Unraveling the crucial role of sleep in the aftermath of sports-related concussions, a recent study underlines how the brain leverages sleep as a self-healing tool, hence emphasizing the clinical severity of such injuries and the potential implications for future treatment strategies.

A 29-member specialist interest group (SIG) was formed, comprising representation from neurology, neuroradiology, anesthesia, neurosurgery, and patient advocacy. The SIG unanimously agreed on the scope and purpose of the guideline. Using a modified Delphi method, the SIG then created guideline statements for a number of question themes. A rigorous literature study, surveys of patients and healthcare professionals, and a review by numerous international experts on SIH all contributed to this process. Any patient presenting with orthostatic headache should be evaluated for spontaneous intracranial hypotension (SIH) and its possible diagnosis. MRI of the brain with contrast and the whole spine should be used as first-line imaging. The non-targeted epidural blood patch (EBP) is the first-line treatment and should be performed as soon as possible. The authors discuss treatment ideas and present criteria for doing myelography based on the spine MRI result and response to EBP. There are also recommendations for conservative care, symptomatic headache treatment, and management of SIH consequences.

Disability and quality of life results were comparable between decompressive craniectomy and craniotomy in individuals with traumatic acute subdural hematoma. More people in the craniotomy group underwent additional surgery, although the craniectomy group experienced more wound issues.

The Abbott Alinity I TBI test is a laboratory-based test that measures ubiquitin C-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein, two biomarkers in the blood that have been linked to brain injury when present in high concentrations. The test has a sensitivity of 96.7% and a negative predictive value of 99.4%. The availability of a blood test provides clinicians with an objective method to quickly evaluate patients with mTBIs while eliminating the need for a head CT scan, potentially reducing health care costs and minimizing emergency department wait times.

To date, no Cdk5 inhibitor has been approved to treat any neuropsychiatric or degenerative diseases due to challenges at the blood-brain barrier. James Bibb, Ph.D., and colleagues seek to change that notion with their brain-permeable compound, 25-106.