Articles related to CLINICAL STUDY

In this target trial emulation involving nearly 44,000 patients with primary hyperparathyroidism (PHPT), similar declines in kidney function at 5 and 10 years were seen in patients managed with parathyroidectomy and in those managed nonoperatively. Thus, in this study, parathyroidectomy had no effect on long-term kidney function in older adults with PHPT.

This summary of a recent French study highlights that patients enabled to infuse apomorphine at home improved QoL more quickly and became more autonomous in managing the device compared with a hospital infusion group. The findings could be helpful to patients who would benefit from continuous subcutaneous apomorphine infusion (CSAI) but are deterred “by the wait for an appointment and the length of the subsequent hospital stay, as well as the physical distance from the nearest specialist center.”

Women who are overweight have an increased risk of developing breast cancer. It is unknown whether prior obesity still carries a higher baseline risk of breast cancer in women who have shed a significant amount of weight as compared to peers without obesity. Researchers assembled a retrospective matched cohort study of 69,260 women who were followed up for 5 years after bariatric surgery or the index date (1/1/2010 – 12/31/2016) to see whether there is a residual risk of breast cancer among patients who undergo bariatric surgery due to prior obesity. According to the findings, bariatric surgery was linked to a lower risk of breast cancer in women with prior obesity that was equivalent to a woman with a BMI under 25, as well as a lower risk when compared to all groups with a BMI of 25 or higher.

In this study published in the Journal of Restorative Dentistry, in both the diabetic and non-diabetic groups, there was no statistically significant difference in the overall pain felt by patients after a single visit and after two visits. Further research on a larger sample size is necessary to definitively determine if diabetes can serve as a disease modifier and alter postoperative pain in irreversible pulpitis following a single-visit RCT in managed T2 diabetics.

According to structural modeling, preschoolers’ and their families’ oral health-related quality of life (OHRQoL) was severely impacted by the severity of early childhood caries (ECC). Weaker socioeconomic position, greater frequency of free sugar consumption, and weaker parental resilience were the key risk factors for the severity of ECC. The results show that psychosocial and behavioral factors might influence how severe ECC is, and that ECC can have a detrimental impact on preschoolers’ welfare and their capacity to carry out everyday tasks as well as on their families’ quality of life.

In a study including 73 meta-analyses and 8,601 unique articles, sugar consumption was associated with 18 endocrine/metabolic outcomes, 10 cardiovascular outcomes, seven cancer outcomes, and 10 other outcomes. Endocrine/metabolic outcomes included weight gain, ectopic fat accumulation, obesity, and cardiovascular disease, which were largely attributed to excessive consumption of fructose containing sugars.