Articles related to CLINICAL STUDY

The study included 186 patients who had recently been diagnosed with advanced lung cancer (Stage IV). Investigators were curious about the relationship between depression levels and systemic inflammation ratio (SIR) biomarker levels at diagnosis. SIRs are made up of three biomarkers that are linked to inflammation in the body, which has been linked to lower survival rates. All participants also filled out a depression questionnaire. According to the findings, 35% of patients had moderate to severe depressive symptoms.

These researchers explain that long-term high fructose intake sustains our primal foraging response, which causes the brain to constantly seek high fat, sugary, and salty foods. When constantly fed, this response can ultimately lead to neural inflammation, creating the conditions that lead to Alzheimer’s.

Plasma P-tau217 significantly predicted longitudinal cognitive decline in both cohorts in this prognostic study of data from two preclinical AD cohort studies involving 171 cognitively unimpaired individuals with cerebrospinal fluid or positron emission tomographic measures of β-amyloid positivity. These findings imply that plasma P-tau217 could be used in clinical trials of novel disease-modifying treatments as a supplement to CSF or PET for participant selection.

Researchers believe that the activity of its flagella, the hair-like projections that help bacteria move around, adhere to, and invade target cells, promotes inflammation in this ‘bacteria x’ species (the name is protected by patent). Previously, the researchers examined fecal samples from patients with relapsing-remitting multiple sclerosis (RRMS) and secondary progressive multiple sclerosis (SPMS), discovering a distinct microbiome profile associated with each MS type. The researchers discovered 12 bacterial species that were particularly enriched in the SPMS samples using bacterial DNA extracted from fecal samples from 62 RRMS and 15 SPMS patients. The highest correlation was found between bacteria X levels and patients’ disability levels, as measured by the Expanded Disability Status Scale (EDSS).

Oregon Health & Science University (OHSU) researchers were searching a genetic database for compounds that could suppress the expression of genes previously linked to heavy alcohol use. They put apremilast to the test in two animal models with a genetic risk of binge drinking, as well as in mice from other labs. In each case, apremilast reduced alcohol consumption by increasing activity in the nucleus accumbens, the brain region involved in controlling alcohol intake. Scripps Research Institute then assessed 51 patients over 11 days of treatment and discovered that trial participants’ alcohol consumption was reduced from an average of five drinks per day to two.

There were significant state variations in racial and ethnic disparities in TNBC incidence in this cohort study, with Black women in Delaware, Missouri, Louisiana, and Mississippi having the highest rates among all states and racial and ethnic populations. More research is needed to identify factors contributing to the significant geographic variations in racial and ethnic disparities in TNBC incidence in order to develop effective preventive measures, and social determinants of health contribute to the geographic disparities in TNBC risk, according to the findings.