Articles related to CLINICAL STUDY

The Aging Cell article, penned by Dorota Skowronska-Krawczyk, PhD, an assistant professor in the departments of physiology & biophysics and ophthalmology and a member of the faculty at the Center for Translational Vision Research at the University of California, Irvine School of Medicine, describes the transcriptional and epigenetic changes occurring in aging retina with the help of her coworkers. The research team demonstrates how stress, such as increased intraocular pressure (IOP) in the eye, promotes epigenetic and transcriptional alterations in retinal tissue that are similar to those associated with aging. And how repeated stress in early retinal tissue causes signs of accelerated aging, such as an accelerated epigenetic age.

The purpose of the randomized controlled study was to see what effect the green-MED diet will have on visceral fat tissue. The randomized controlled study, which lasted 18 months, involved 294 participants in all. Three groups of participants were created: the HDG (healthy dietary recommendations), the MED diet, and the green-MED diet. Participants in both MED groups consumed 440 mg of polyphenols and 28 g of walnuts daily. The green-MED group also ingested three to four cups of green tea daily, 100 g of frozen duckweed plant green smoothie, 800 mg of polyphenols daily, and less meat.

In a study of more than 800 rural-living men and women with knee osteoarthritis, an 18-month program of diet and exercise versus attention control yielded an average 14-pound greater weight loss in the test group – but not much difference in pain magnitude.

The presence of vitamin D in the brain and its link to improved cognitive performance in aged subjects was originally discovered by a Tufts University study. Higher vitamin D concentrations were linked to a 25% to 33% decreased risk of dementia or mild cognitive impairment in four different brain areas. Authors did note, however, that the observational nature of the study and the lack of a diverse subject population were two of its drawbacks, and there may be further explanations for the results.

This 10-year study is the first large, population-based assessment of spasticity treatment in MS. It reveals that younger, newly diagnosed people are prescribed baclofen more their older peers. This is the first study to show high rates of baclofen discontinuation among all patients with MS, with more than 50% of patients discontinued treatment within 6 months.

For the treatment of psychosis in schizophrenia, may an oral molecule constitute a new class of psychotropic drug with a non-D2-receptor binding mode of action? The purpose of a recent study was to answer that question, which Dr. Matt Birnholz delves into in this audio abstract.