Articles related to CLINICAL STUDY

Shift work has previously been linked to an increased risk of developing MS, presumably due to the resulting sleep deprivation and circadian desynchrony. The current study compared sleeping 7–9 hours/night during adolescence, with less than 7 hours/night and found a 40% increase in risk for developing MS in the short-sleep cohort. The authors conclude that “insufficient sleep and low sleep quality during adolescence seem to increase the risk of subsequently developing MS.”

The number and quality of available studies on ketamine plus psychotherapy are limited because of the newness of the therapy. However, in the 4 studies deemed eligible for review, ketamine plus psychotherapy—regardless of protocol—was associated with significant symptom reduction.

According to the findings of the study, gabapentin should not be used on a regular basis. Individualization is required, based on the type of pain and the risk of delirium. If gabapentin is used to control postoperative pain, it must be closely monitored for the development of delirium. Low-dose opioids, along with nonpharmacologic pain management strategies such as postoperative physical therapy and mobilization, can still be used safely in the study population. Rather than relying on a single medication, a more holistic approach to postoperative pain control in the hospital setting is required.

In this study, more than 12,000 patients 18 years and older with hospitalization for extremity fracture were randomized to LWMH or aspirin. Rates of DVT were 1.7% and 2.5%, respectively. PE, bleeding complications, and other SAEs were similar across groups. Death occurred in 0.73% and 0.78% respectively for LWMH and aspirin.

Greater adherence to a number of healthy eating patterns was linked to a lower risk of death in this cohort study, which included 44,085 men and 75,230 women from the Health Professionals Follow-Up Study (1986-2020) and the Nurses’ Health Study (1984-2020). These relationships held true for persons who were Hispanic, non-Hispanic Black, and non-Hispanic White, as well as for other racial and ethnic groupings.

This large cohort study evaluated the frequency of 70 long COVID outcomes in unvaccinated individuals with mild COVID infection matched to uninfected individuals and to vaccinated individuals. Anosmia and dysgeusia were the most frequently reported long COVID symptoms with the risk being dramatically increasing at 30 days to 6 months post infection and falling rapidly thereafter. Mild COVID generated an 85% increased risk of cognitive impairment an 80% increased risk of dyspnea and weakness and a nearly 50% increased risk for palpitations. The findings were consistent across all COVID variants and were more marked in adults than children. Vaccinated individuals with breakthrough infection had similar risk for all these outcomes with the exception of dyspnea, for which the risk was lower in vaccinated persons.