Articles related to GUIDELINES/RECOMMENDATIONS

A systematic review identified 204 eligible publications from 2000 through 2017, with much of the evidence consisting of systematic reviews of observational data, consensus guidelines, case series, and case reports. Due to the paucity of high-quality evidence on management of immune-related adverse events, recommendations are based on expert consensus.

Research from 20 years (2000 -2020) of studies (293) inform the evidence base for this guideline from ASCO, which addressed six main clinical questions/subquestions on preoperative evaluations, surgical diagnostic and therapeutic procedures, appropriate radiotherapy techniques, the role of systemic therapy, and follow-up evaluations.

Bowing to criticism from doctors, the National Comprehensive Cancer Network (NCCN) has again updated its guidelines for prostate cancer. The previous update, released this past September, had changed the recommendation about active surveillance for low-risk prostate cancer to state that active surveillance was no longer the “preferred” management option for patients with low-risk prostate cancer and a life expectancy of 10 years or more. Many physicians criticized this change, saying it could lead to overtreatment of low-risk patients by implying that active surveillance, surgery, and radiation are equivalent management options. As a result, NCCN has further revised its guidelines to now state that active surveillance is preferred for most patients with low-risk prostate cancer and a life expectancy of 10 years or more.

The updated NCCN guidelines no longer say that active surveillance is “preferred” for low-risk prostate cancer, prompting some physicians to claim this recommendation may encourage overtreatment and is a “step back” from progress made over the last decade, which has been defined by active surveillance as the preferable care option for most low-risk localized prostate cancer patients.

In practice, “standard” duration of antibiotic therapy is often based on archaic studies. Newer evidence shows that shorter durations are often a better choice and that antibiotic resistance is more likely to develop with longer durations of therapy. Here are the recommendations applied to four commonly treated infections.

Available from Guideline Central, the free, quick-reference print and digital pocket guide covers the most recent American Society of Clinical Oncology (ASCO) Hepatocellular Carcinoma Guidelines. Accessed by web and offline mobile devices, the pocket guide covers key points, treatment, first- and second-line therapies, a downloadable PDF, and links to other resources in advanced hepatocellular carcinoma.