Articles related to MOVEMENT DISORDERS

Athira’s safety and efficacy trial, geared for 75 patients, will run with a smaller-than-planned 28 patient study population. The trial is for the small molecule fosgonimeton, an activator of the HGF/MET pathway, postulated to offer neuroprotective effects to improve brain function in patients with Parkinson’s dementia.

Exablate Neuro from Insightec targets and removes a tiny part of the globus pallidus using precision MRI-guided focused ultrasound. This reduces activity and motor symptoms like tremor and stiffness. During the procedure, patients are awake, allowing doctors to detect immediate effects and adjust as needed. There is no need for anesthesia or a hospital stay following the procedure. Exablate Neuro, unlike deep brain stimulation, does not require any surgical incisions or brain implants. Additionally, the technique reduces the risk of serious infection or brain bleeding.

Multiple studies’ pooled data revealed a significantly increased risk of Parkinson’s when combined with bullous pemphigoid, a rare skin condition, inflammatory bowel disease (IBD), or Sjögren’s syndrome. Immune response impairment has been linked to Parkinson’s disease in a growing body of evidence. Indeed, some studies have suggested that the neurodegenerative disease may be exacerbated by autoimmune processes, which occur when the immune system incorrectly attacks and destroys healthy tissue.

Per Svenningsson, MD, PhD, a neurologist with expertise in Parkinson’s disease, will serve as the multicenter trial’s principal investigator. He previously oversaw a clinical study using montelukast (Singulair) tablets to treat PD. The multicenter trial is anticipated to begin between July and September. During the 18-month trial, participants will be randomized to receive either montelukast VersaFilm or a placebo film. IntelGenx plans to use the results to enhance the clinical development of its montelukast VersaFilm for Parkinson’s.

It wasn’t carpal tunnel. It wasn’t just anxiety, and Ed wasn’t having a stroke. Even after a complete neurological assessment, it wasn’t “mild cognitive impairment.” For months, Ed’s life was plagued with psychiatric and movement disorders that puzzled his wife and his physicians. Read the narrative about how Ed was finally diagnosed, what happened next, and where he is now.

Of the four most commonly prescribed antiepileptic drugs (AEDs) in the UK, carbamazepine wasn’t significantly associated with Parkinson’s, but three AEDs did have a significant relationship, including lamotrigine, levetiracetam, and sodium valproate.