The lesion had been present for approximately 4 years in this healthy adolescent male.Physical examination reveals a 0.3-cm firm papule with a brownish hue and no similarlesions elsewhere. What is the diagnosis?

Our system is strained and we don’t have a solution for it. But is the strain impactingpatient care? This review of an article published in the Journal of HospitalMedicine seems to say that higher patient loads lead to longer patient stays.

These data suggest that a negative rapid antigen test in individuals with residualsymptoms could provide reassurance about ending isolation.

Anal intercourse is becoming more common among heterosexual couples. In the US, 30-44% of men and women report experience of anal sex. There are a host ofnegative health implications, especially for women, that should be communicatedespecially so patients can make truly informed decisions.

The author concludes that “careful use of T3  and L-T4  can be critical mood-stabilizingoptions, especially for depressive illness that has not responded to first-line therapies,and can provide an alternative to other augmentation strategies such as atypicalantipsychotics, lithium, or esketamine/ketamine.”

This study enrolled individuals with AD who had been on a stable dose of donezepil forat least 90 days. They were then treated for 12 weeks with the addition of themodulator of cholinergic neurotransmission AD101, or placebo. Those receiving AD101had mean improvement of approximately 2 points on the Alzheimer DiseaseAssessment Scale-Cognitive (ADAS-Cog) Subscale. Individuals who had continued donezepil plusplacebo showed declines on ADAS-Cog.