In the absence of contraindications, metformin should be seriously considered as an off-label initial therapy and as an adjunct to antiobesity medications approved by the US Food and Drug Administration.

It’s not clear what causes leg cramps. But researchers believe some things can trigger cramps, such as: dehydration, electrolyte imbalances, muscle fatigue.

All interventional procedures supported by moderate or low certainty evidence showed little to no pain relief compared with sham procedures.

The NRMP has actively engaged in discussion about the physician pipeline and stands ready to provide data and information that further inform the conversation.

It seems likely that the patient didn’t understand the seriousness of his condition – the fact that he didn’t return for months after being instructed to do so sooner seems to indicate this.

Preemptive TIPS has been shown to improve overall mortality in patients with variceal hemorrhage… the 1-year probability of remaining free of failure to control bleeding was 97% in the preemptive TIPS group vs 50% in standard-of-care group.