Articles related to Hospital Medicine

A quartet of current clinical trials involving first-in-class molecules and CRISPR gene editing show great promise. STELLAR investigates a fusion protein in PAH, CodeBreak 200 studies a first-in-class of KRAS inhibitor, EMERGENT-2 focuses on a new treatment for schizophrenia, and NCT04601051 studies a gene editing drug for one form of amyloidosis.

Although many organizations advise reducing the range of antibiotic therapy for hospitalized patients in light of laboratory findings, some are challenging the validity of the practice. One expert argued that there are insufficiently strong data on spectrum de-escalation to determine whether it improves outcomes.

To assess short-term risk for severe cardiovascular events (excluding myocarditis and pericarditis) after COVID-19 vaccination, adults younger than 75 years hospitalized for PE, acute MI, hemorrhagic stroke, or ischemic stroke (73,325 events) were reviewed in relation to a 1st or 2nd COVID vaccine dose. No association was found between the Pfizer–BioNTech or Moderna vaccine and severe cardiovascular events. The first dose of the Oxford–AstraZeneca vaccine was associated with acute MI and PE in the second week after vaccination. An association with MI in the second week after a single dose of the Janssen vaccine could not be ruled out.

There are other methods to push learners, according to hospitalist Dr. Benjamin Kinnear. “If you want to make them feel more stressed, give them more difficult assignments or test their clinical judgment; don’t try to make them feel challenged by making them feel inferior.”

Our system is strained and we don’t have a solution for it. But is the strain impactingpatient care? This review of an article published in the Journal of HospitalMedicine seems to say that higher patient loads lead to longer patient stays.

These data suggest that a negative rapid antigen test in individuals with residualsymptoms could provide reassurance about ending isolation.