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Journal of Clinical OncologyLandscape of KRAS(G12C), Associated Genomic Alterations, and Interrelation w. Immuno-Oncology Biomarkers in KRAS-Mutated Cancers

The KRASG12C mutation was more prevalent in females and older patients and appeared to be associated with smoking status. KRASG12C tumors exhibited a distinct co-mutation profile and were associated with tumor mutational burden-high status.