Articles related to AUTOIMMUNE DISORDERS

The human monoclonal antibody could be the treatment polymyalgia rheumatica patients experiencing relapses during glucocorticoid tapering have been waiting for.

Understanding the MTHFR gene mutation can significantly impact patient care, especially when prescribing folic acid supplements or fortified foods. Learn how this mutation affects folate metabolism and the increased risks for various health conditions.

This recent study suggests that thymectomy may have significant implications for patients’ overall health, with an observed increase in mortality and cancer risk. As physicians, it’s crucial to consider these findings in your surgical practices and patient care strategies.

Explore the intriguing connections between postural orthostatic tachycardia syndrome (POTS) and autoimmune disorders. This comprehensive review offers insights into diagnosis, potential autoimmune mechanisms, and future directions in the field, providing valuable information for practitioners dealing with this complex condition.

Despite striking parallels in symptomatology between POTS and autoimmune disorders, a deeper scrutiny reveals that this overlap may not be sufficient to definitively attribute an autoimmune cause to POTS; hence, indiscriminate application of immunosuppressive therapies should be re-evaluated.

Researchers discovered that inhibiting the activity of the fumarate hydratase enzyme in macrophages (a type of immune cell that plays a key role in inflammatory disorders) increased the cells’ production of interferon-beta. They also discovered that lupus patients’ macrophages have abnormally low levels of fumarate hydratase. These findings suggest that dysregulation of this enzyme may be a factor in the development of lupus, and that fumarate hydratase could be a potential therapeutic target.