Articles related to CLINICAL STUDY

A cohort study of 1,024 patients at an urban academic medical center discovered that 13% of oral anticancer drug prescriptions were never filled. The most common reason for failure to receive an oral anticancer drug prescription was due to patient and clinician decision-making; 13% of cases of failure to receive an oral anticancer drug prescription were directly associated with financial access issues.

In a cohort study of more than 2 million patients, influenza vaccination was associated with a 22% to 24% lower risk of SARS-CoV-2 infection. But more than half of that effect seems to be that healthier people are more likely to be vaccinated for flu.

In this retrospective cross-sectional study of patients hospitalized for suspected infection, temporal temperature measurement was associated with a lower odds of detecting fever compared with oral measurement in Black patients but not white patients. “Health care systems routinely use fever cutoffs to trigger notification pathways such as sepsis alerts to systematize timely triage and antibiotic administration. Although the absolute difference between oral and temporal temperatures was small, the findings suggest that this discrepancy combined with commonly used fever cutoffs may lead to fever going undetected in many Black patient.” Sivasubramanium V. Bhavani, MD

In this study involving 452 patients with diagnoses of MDD, GAD, and PTSD, IM ketamine reduced depression by 38% and anxiety by 50%, with persistence over 7 months of maintenance therapy.

Some studies in children have reported a relationship between antidepressant use in pregnancy and neurodevelopment disorders after birth. In this analysis of 145,702 antidepressant-exposed and 3,032,745 unexposed pregnancies, crude results suggested up to a doubling in risk of neurodevelopmental outcomes. Significantly, however, no association was observed after balancing for confounding variables.

An observational analysis reviewed 54 studies and two medical record databases with data for 1.2 million individuals, to determine how many people experienced at least 1 of the 3 self-reported Long COVID symptom clusters 3 months after infection. The results indicate a Long COVID rate of 6.2%: 3.7% for ongoing respiratory problems, 3.2% for persistent fatigue with bodily pain or mood swings, and 2.2% for cognitive problems.