Articles related to CLINICAL STUDY

The idea that depression is brought on by decreased serotonin activity or concentrations is unsupported, according to the authors of a systematic umbrella review, who also challenge the rationale behind the high rates of antidepressant prescription. They claim that certain medical professionals continue to promote the incorrect chemical imbalance explanation of depression, and the public as a whole still accepts it. However, other medical professionals argue that antidepressants continue to be a helpful treatment option for patients in addition to other methods like talking therapy and that the idea that depression is caused by a straightforward chemical imbalance is outdated in any case.

Many academic neurologists, especially younger faculty, are not fully aware that clinical service activities are the main source of medical school funding. The time for research and teaching has decreased, and transparent discussions of these problems and possible solutions are not common. This article strives to discuss the needed balance between education, clinical services, and advancing research.

Using covariate analysis of records from more than 1.2 million children over 17 years, these researchers conclude that the elevated risk for neonatal seizures and childhood epilepsy in children who were exposed to SSRIs or SNRIs during pregnancy can be attributed to the indicated SSRI and SNRI use for pregnant women, history of parental epilepsy, and other covariates, rather than the use of the medication itself.

The knee arthritis meta-analysis reviewed 169 trials involving 21,163 patients, with the evidence demonstrating viscosupplementation is associated with a clinically irrelevant reduction in pain intensity and with an increased risk of serious adverse events compared with placebo. For the meniscus study, the commentary may sum it up best: “Multiple studies, including several with sham surgeries as a control have shown repeatedly over the previous 2 decades that surgery is not superior to physical therapy, yet the issue and use of surgery persist.”

The study confirmed the high unmet need among older adults with AML, namely that overall survival (OS) without transplant is poor and consistent with other studies. The authors also remark that a “definitive evidence-based recommendation favoring venetoclax and azacitidine (ven/aza) or CPX-351 in older adults will require a randomized trial.”

The study was comprised of 17,913 men with a median age of 64 years with pT2-4N1M0 prostate cancer (PC) consecutively treated between 1995 and 2017, with postradical prostatectomy (RP) and pelvic lymph node (LN) assessment. The patients were then followed for possible treatment with adjuvant radiation therapy (aRT) or early salvage radiation therapy (sRT). It was determined that men with pN1 PC and 4 or more as compared with 1-3 positive pelvic LNs appear to benefit the most from the use of aRT.